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NUPACK is a growing software suite for the analysis and design of nucleic acid structures, devices, and systems, serving researchers in the emerging disciplines of molecular programming, nucleic acid nanotechnology, synthetic biology, and across the life sciences.

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All-new NUPACK cloud web app

The all-new NUPACK cloud web app (manuscript) leverages a scalable hybrid cloud compute cluster and the all-new NUPACK 4 scientific code base:

enhanced physical models (coaxial and dangle stacking)
dramatic speedups (20-120x for test tube analysis)
increased scalability for large complexes
diverse hard and soft sequence constraints for design
Interacting Strands

NUPACK algorithms are unique in treating complex and test tube ensembles containing arbitrary numbers of interacting strand species, providing crucial tools for capturing concentration effects essential to analyzing and designing intermolecular interactions that are a hallmark of these fields.

NUPACK Web App Subscription

Subscribe to the NUPACK web app to run jobs on the scalable NUPACK hybrid cloud.This alpha test site is in a temporary free testing mode. We are in the process of implementing user fees that will help make NUPACK a sustainable resource for the research community.

For technical support, feature requests, or bug reports, please contact us at support@nupack.org.

– The NUPACK Team